Recent discoveries

The choroid plexus (CP) plays a crucial role in supporting the central nervous system (CNS) by producing cerebrospinal fluid, facilitating brain-immune interactions, removing waste, and releasing proneuronal signals.

Despite its physiological importance, the CP's role in neurological diseases is often overlooked. Interactions between resident CNS cells like microglia and peripheral immune cells can lead to inflammation, creating a neurotoxic environment associated with neuroinflammatory diseases. Additionally, metabolic disturbances can damage neurons and their supporting cells, resulting in neurodegeneration. Research suggests that neuroinflammatory and neurodegenerative conditions share significant similarities, linked by core CP abnormalities such as immune cell infiltration, barrier breakdown, and impaired clearance of neurotoxins. This highlights the necessity of studying both conditions in parallel to enhance understanding and management of neuroinflammation and neurodegeneration.

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A person wearing a blue protective suit and mask is working in a laboratory setting. They are handling petri dishes on a counter with a digital display and laboratory equipment nearby. The room has clean, white walls and a blue door.
A person wearing a blue protective suit and mask is working in a laboratory setting. They are handling petri dishes on a counter with a digital display and laboratory equipment nearby. The room has clean, white walls and a blue door.
A man with a beard and glasses is wearing a white coat and a stethoscope around his neck. His arms are crossed, and he appears confident and professional. The background is plain and light-colored.
A man with a beard and glasses is wearing a white coat and a stethoscope around his neck. His arms are crossed, and he appears confident and professional. The background is plain and light-colored.

Our Publications:

Explore Dr. Putterman's extensive research publications, showcasing advancements in medicine, immunology, and microbiology from his work at leading institutions.

The choroid plexus (CP) plays a crucial role in supporting the central nervous system (CNS) by producing cerebrospinal fluid, facilitating brain-immune interactions, removing waste, and releasing proneuronal signals.

Despite its physiological importance, the CP's role in neurological diseases is often overlooked. Interactions between resident CNS cells like microglia and peripheral immune cells can lead to inflammation, creating a neurotoxic environment associated with neuroinflammatory diseases. Additionally, metabolic disturbances can damage neurons and their supporting cells, resulting in neurodegeneration. Research suggests that neuroinflammatory and neurodegenerative conditions share significant similarities, linked by core CP abnormalities such as immune cell infiltration, barrier breakdown, and impaired clearance of neurotoxins. This highlights the necessity of studying both conditions in parallel to enhance understanding and management of neuroinflammation and neurodegeneration.

In this study, we establish, validate, and apply a CP spheroid model to the study of B-CSFB function in lupus.

Our results show that IL-6, a key cytokine increased in NPSLE, can potentially suppress the CP-specific function and expression of BCRP and MRP1. Therefore, IL-6 could affect the CSF clearance of inflammatory substrates (e.g., leukotrienes), the accumulation of which would incite neurotoxicity and promote progression of NPSLE.

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Research Publications

Explore Dr. Putterman's extensive research contributions in medicine and microbiology.

A person in protective attire, including a bright green suit, gloves, a face mask, and a hair cap, is working in a laboratory setting. They are holding a syringe and appear to be performing some tests or experiments. Numerous test tubes, some with red caps and filled with liquid, are organized on a table. The room has scientific equipment, including a centrifuge, and blue curtains allow natural light to filter through the window.
A person in protective attire, including a bright green suit, gloves, a face mask, and a hair cap, is working in a laboratory setting. They are holding a syringe and appear to be performing some tests or experiments. Numerous test tubes, some with red caps and filled with liquid, are organized on a table. The room has scientific equipment, including a centrifuge, and blue curtains allow natural light to filter through the window.
A person wearing a lab coat is using a microscope, seemingly focused and engaged in scientific observation. The setting suggests a laboratory environment with beakers and scientific tools visible in the background.
A person wearing a lab coat is using a microscope, seemingly focused and engaged in scientific observation. The setting suggests a laboratory environment with beakers and scientific tools visible in the background.
Two scientists in a laboratory, both wearing white lab coats and protective eyewear. The scientist in the foreground is using a pipette, while the one in the background is working on a computer. Various laboratory equipment and supplies are visible around them.
Two scientists in a laboratory, both wearing white lab coats and protective eyewear. The scientist in the foreground is using a pipette, while the one in the background is working on a computer. Various laboratory equipment and supplies are visible around them.
A microscopic image showcasing a cluster of cells. The cells are vibrant with green, red, and blue fluorescence, indicating various staining or molecular labeling. The majority of the cells are tightly packed in the upper portion, while fewer cells are scattered below against a dark background.
A microscopic image showcasing a cluster of cells. The cells are vibrant with green, red, and blue fluorescence, indicating various staining or molecular labeling. The majority of the cells are tightly packed in the upper portion, while fewer cells are scattered below against a dark background.

Explore groundbreaking studies in medicine and immunology.

Contacts:

chaim.putterman@biu.ac.il

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